মঙ্গলবার, ১৪ মে, ২০১৩

BlackBerry announces new Android support in enterprise management suite

BlackBerry Live

The better part of the CrackBerry crew are at BlackBerry Live 2013 this week, and there was a bit of news for Android fans amid the general session. BlackBerry Enterprise Service 10.1 was announced, which includes support for Android devices. That means your IT guy can roll out apps and lock down BlackBerry devices throughout the company just as easily as it can with any Android devices. 

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Source: http://feedproxy.google.com/~r/androidcentral/~3/rcIT8ot67JU/story01.htm

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How does Benghazi affect Clinton? (CNN)

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সোমবার, ১৩ মে, ২০১৩

Tesla Motors: Lots of buzz. Is it warranted?

Tesla Motors is a bright spot?amid high-profile, federally-funded electric car flops. Tesla Founder Musk has found a way to bring high-tech pizzazz to a 'green' car drawing comparisons to Steve Jobs and Apple.

By David J. Unger,?Correspondent / May 10, 2013

Tesla Motors CEO Elon Musk speaks at his company's factory in Fremont, Calif. Tesla is among perhaps only a handful of companies that have changed the way consumers think about alternative energy.

Noah Berger/Reuters/File

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Tesla Motors had a good week.

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Why It Matters

Energy: The transportation sector consumes 70 percent of the oil used in the US. EVs can held diminish that reliance.?

Environment: Depending on where their electricity comes from, EVs could reduce greenhouse gas emissions.

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The luxury electric carmaker posted its first profit late Wednesday. The next day, Tesla's Model S tied for Consumer Reports? highest testing score ever. Wall Street rejoiced, pushing shares of Tesla up 24 percent on the news.

Tesla Motors is a bright spot?amid high-profile, federally-funded electric car flops. CEO Elon Musk's innovative approach to carmaking suggests the energy industry can benefit from borrowing a page from the tech sector's playbook.

The two sectors have borne some resemblence of late. New computer software has changed the way we look for oil. Smart thermostats are saving on residential energy consumption. The lithium-ion batteries that have powered our consumer electronics for a decade, are beginning to transform the way we fuel our cars. ?

But if you're expecting the electrical grid to transform as quickly as the superconductor, you may be disappointed.?

Magia Maledicto

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Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/vwmCbGJoHfg/viewtopic.php

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রবিবার, ১২ মে, ২০১৩

'Gatsby' gives 'Iron Man 3' a run for its money

This film publicity image released by Warner Bros. Pictures shows Leonardo DiCaprio as Jay Gatsby in a scene from "The Great Gatsby." (AP Photo/Warner Bros. Pictures)

This film publicity image released by Warner Bros. Pictures shows Leonardo DiCaprio as Jay Gatsby in a scene from "The Great Gatsby." (AP Photo/Warner Bros. Pictures)

This film publicity image released by Disney-Marvel Studios shows Robert Downey Jr., left, as Tony Stark/Iron Man and Gwyneth Paltrow as Pepper Potts in a scene from "Iron Man 3." (AP Photo/Disney, Marvel Studios)

(AP) ? Gatsby looks almost as great as a superhero at the weekend box office.

Leonard DiCaprio's "The Great Gatsby" partied like it was the Roaring '20s with a $51.1 million debut that made it a surprisingly strong runner-up to comic-book blockbuster "Iron Man 3."

Studio estimates Sunday put "Gatsby" at No. 2 behind Robert Downey Jr.'s superhero sequel, which pulled in $72.5 million domestically to raise its total to $284.9 million after just 10 days in U.S. theaters.

With an additional $89.3 million in its third weekend overseas, "Iron Man 3" lifted its international total to $664.1 million and its worldwide haul to $949 million.

"The Great Gatsby" far exceeded expectations by distributor Warner Bros. of a $35 million to $40 million opening weekend.

Director Baz Luhrmann's 3-D adaptation of the F. Scott Fitzgerald classic was a rare box-office smash for films aimed at older adults during the youth-minded summer season. According to Warner Bros., viewers over 25 made up 69 percent of the film's audience.

"It answers the question that you and I hear all the time from people over 50, 'There's nothing for me to see,'" said Dan Fellman, the studio's head of distribution. "While every studio has the $200 million tentpoles in the marketplace, you still have those who feel that it's not directed at them, which is true. So that's why I think counterprogramming like this is very important."

The weekend's other new wide release, Lionsgate's romantic comedy "Peeples," flopped at No. 4 with just $4.9 million. Produced by Tyler Perry, the movie stars Craig Robinson and Kerry Washington in a meet-the-parents-style farce.

Getting a head start on its domestic launch Friday, "Star Trek: Into Darkness" opened with $31.7 million in seven international markets. Its overseas debut included $13.3 million in Great Britain, $7.6 million in Germany and $5.5 million in Australia.

Starring DiCaprio in the title role as 1920s mystery millionaire Jay Gatsby, the latest Fitzgerald update co-stars Carey Mulligan as his lost love and Tobey Maguire as the friend chronicling their doomed romance.

It was by far the biggest debut ever for filmmaker Luhrmann, whose previous best was $14.8 million for "Australia." In just one weekend, "The Great Gatsby" nearly matched the $57.4 million domestic haul that Luhrmann's top-grossing film, the musical "Moulin Rouge!", managed in its entire run.

"Gatsby" also gave DiCaprio his second-biggest debut, behind the $62.8 million take for "Inception."

The film's success follows a bumpy road to theaters. Originally scheduled for release last December, Warner Bros. pushed it back to summer to give Luhrmann more time to finish his elaborate visual spectacle.

How well the film holds up in coming weeks depends on word-of-mouth from fans. Reviews for "The Great Gatsby" have been so-so, with many critics saying it sacrifices drama and substance for style and dazzle, including Lurhmann's elaborate party scenes backed by a contemporary soundtrack featuring Jay-Z, Beyonce and Lana Del Rey.

"Iron Man 3" was down a steep 58 percent from its opening weekend haul, no surprise given that its $174.1 million domestic debut was the second-biggest ever. The only film to do more business was Downey and company's ensemble adventure "The Avengers," which topped $200 million in its premiere last year.

"The Avengers" held up better in its second weekend with $103.1 million, a drop of only 50 percent. But "Iron Man 3" is on its way to becoming the biggest solo superhero hit worldwide and the second-biggest comic-book adaptation, behind the $1.5 billion "Avengers" payday.

"This is on a trajectory like no other individual superhero movie we've ever seen," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "In less than three weeks, this thing is honing in on a billion dollars. It's just a testament to the incredible popularity of this character."

The movie already has far surpassed the franchise best of $624 million worldwide for "Iron Man 2."

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.

1. "Iron Man 3," $72.5 million ($89.3 million international).

2. "The Great Gatsby," $51.1 million.

3. "Pain and Gain," $5 million.

4. "Peeples," $4.9 million.

5. "42," $4.7 million.

6. "Oblivion," $3.9 million ($11.7 million international).

7. "The Croods," $3.6 million ($17.3 million international).

8. "The Big Wedding," $2.5 million ($2 million international).

9. "Mud," $2.4 million.

10. "Oz the Great and Powerful," $802,000.

___

Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:

1. "Iron Man 3," $89.3 million.

2. "Star Trek: Into Darkness," $31.7 million.

3. "The Croods," $17.3 million.

4. "Oblivion," $11.7 million.

5. "Les Profs," $3.7 million.

6. "Boomerang Family," $3.6 million.

7. "Scary Movie 5," $2.7 million.

8. "Evil Dead," $2.6 million.

9. "Hanni and Nanni 3," $2.3 million.

10. "The Big Wedding," $2 million.

___

Online:

http://www.hollywood.com

http://www.rentrak.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-12-Box%20Office/id-ab41d43b4c5b4bd2b2fee9d9a48c0091

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Take that, iPad mini: Retina display Nexus 7 at Google I/O says analyst

While Apple fans are waiting for an iPad mini with improved screen, Android enthusiasts may see the Nexus 7 get its own Retina display next week. KGI Securities?analyst?Ming-Chi Kuo penned a research note that AppleInsider read and Kuo expects Google?s small slate to gain a 1920 x 1200 display at Google?s I/O Developer event, which takes place May 15 to May 17.

Kuo?s expectations aren?t that different from earlier Reuters reports,?whose sources in April indicated a high-resolution display, faster processor and doubling of device memory to 2 GB coming to the next model Nexus 7. Reuters suggested a 1920 x 1080 panel at 315 pixels per inch, while Kuo figures a 1920 x 1200 display at 323 PPI.

A Qualcomm APQ8064 chip will power the updated tablet, says Kuo, which is the same Snapdragon 600 currently used in the LG Optimus G Pro, Samsung Galaxy S 4 and HTC One smartphones.?Wireless charging, an LTE option, 5 megapixel rear camera and Android 4.3 are also expected by the analyst.

These specifications sound right to me and I do expect Google to introduce a refreshed Nexus 7 at its developer event. I don?t think, however, that Google will be able to maintain the $199.99 current starting price for an updated Nexus 7. Even if the device comes in at a $249 to $299 range for a base Wi-Fi model, it?s less than Apple?s non-Retina iPad mini, which is $329. I still give some advantage to the iPad line, however, as I see more applications optimized for higher-resolution screens on iOS than on Android.

Source: http://gigaom.com/2013/05/10/take-that-ipad-mini-retina-display-nexus-7-at-google-io-says-analyst/

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Today in History

Today is Sunday, May 12, the 132nd day of 2013. There are 233 days left in the year. This is Mother's Day.

Today's Highlights in History:

On May 12, 1943, during World War II, Axis forces in North Africa surrendered. The two-week Trident Conference, headed by President Franklin D. Roosevelt and British Prime Minister Winston Churchill, opened in Washington.

On this date:

In 1780, during the Revolutionary War, the besieged city of Charleston, S.C., surrendered to British forces.

In 1870, an act creating the Canadian province of Manitoba was given royal assent, to take effect in July.

In 1922, a 20-ton meteor crashed near Blackstone, Va.

In 1932, the body of Charles Lindbergh Jr., the kidnapped son of Charles and Anne Lindbergh, was found in a wooded area near Hopewell, N.J.

In 1933, the Federal Emergency Relief Administration and the Agricultural Adjustment Administration were established to provide help for the needy and farmers.

In 1937, Britain's King George VI was crowned at Westminster Abbey; his wife, Elizabeth, was crowned as queen consort.

In 1949, the Soviet Union lifted the Berlin Blockade, which the Western powers had succeeded in circumventing with their Berlin Airlift.

In 1958, the United States and Canada signed an agreement to create the North American Air Defense Command (later the North American Aerospace Defense Command, or NORAD).

In 1963, Betty Miller became the first woman to fly solo across the Pacific Ocean as she landed her Piper Apache in Brisbane, Australia, having left Oakland, Calif., on April 30, making three stopovers along the way.

In 1970, the Senate voted unanimously to confirm Harry A. Blackmun as a Supreme Court justice.

In 1982, in Fatima, Portugal, security guards overpowered a Spanish priest armed with a bayonet who attacked Pope John Paul II. (In 2008, the pope's longtime private secretary revealed that the pontiff was slightly wounded in the assault.)

In 2002, Jimmy Carter arrived in Cuba, becoming the first U.S. president in or out of office to visit since the 1959 revolution that put Fidel Castro in power.

Ten years ago: Suicide bombers attacked foreigners' housing compounds in Riyadh, Saudi Arabia, killing 25 victims. A suicide truck-bomb attack killed at least 60 at a government compound in northern Chechnya. L. Paul Bremer, the new American civilian administrator of Iraq, arrived in Baghdad; coalition forces announced they had taken custody of Dr. Rihab Rashid Taha (TAH'-hah), the Iraqi scientist known as "Dr. Germ." (Taha was later released after no charges were brought.) The Texas House ground to a standstill after 51 Democratic lawmakers left the state in a dispute over a Republican congressional redistricting plan. (The Democrats returned four days later from Oklahoma, having succeeded in killing the bill.)

Five years ago: A devastating earthquake in China's Sichuan province killed some 70,000 people. Nearly 400 workers were arrested in an immigration raid at a kosher meatpacking plant in Postville, Iowa. Irena Sendler, credited with saving some 2,500 Jewish children from the Holocaust, died in Warsaw, Poland, at age 98. Pop artist Robert Rauschenberg died on Captiva Island, Fla, at age 82. Indians second baseman Asdrubal Cabrera turned the 14th unassisted triple play in major league history during the second game of a doubleheader against Toronto. NBC announced that Jimmy Fallon would succeed Conan O'Brien as host of "Late Night."

One year ago: At least 100,000 Spaniards angered by grim economic prospects and the political handling of the international financial crisis turned out for street demonstrations, marking the one-year anniversary of a spontaneous movement that inspired similar protests elsewhere. Miami's LeBron James became the eighth player in NBA history to win the MVP award three times.

Today's Birthdays: Baseball Hall-of-Famer Yogi Berra is 88. Critic John Simon is 88. Composer Burt Bacharach is 85. Actress Millie Perkins is 75. Rhythm-and-blues singer Jayotis Washington is 72. Country singer Billy Swan is 71. Actress Linda Dano is 70. Musician Ian McLagan is 68. Actress Lindsay Crouse is 65. Singer-musician Steve Winwood is 65. Actor Gabriel Byrne is 63. Actor Bruce Boxleitner is 63. Singer Billy Squier is 63. Country singer Kix Brooks is 58. Actress Kim Greist is 55. Rock musician Eric Singer (KISS) is 55. Actor Ving Rhames is 54. Rock musician Billy Duffy is 52. Actor Emilio Estevez is 51. Actress April Grace is 51. Actress Vanessa A. Williams ("Melrose Place") is 50. Country musician Eddie Kilgallon is 48. Actor Stephen Baldwin is 47. Actor Scott Schwartz is 45. Actress Kim Fields is 44. Actress Samantha Mathis is 43. Actress Jamie Luner is 42. Actor Christian Campbell is 41. Actress Rhea Seehorn is 41. Actor Mackenzie Astin is 40. Actress Malin (MAH'-lin) Akerman is 35. Actor Jason Biggs is 35. Actress Emily VanCamp is 27. Actor Malcolm David Kelley is 21. Actors Sawyer and Sullivan Sweeten ("Everybody Loves Raymond") are 18.

Thought for Today: "A mother becomes a true grandmother the day she stops noticing the terrible things her children do because she is so enchanted with the wonderful things her grandchildren do." ? Lois Wyse, American advertising executive, author and columnist (1926-2007).

(Above Advance for Use Sunday, May 12)

Copyright 2013, The Associated Press. All rights reserved.

Source: http://news.yahoo.com/today-history-050206767.html

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শনিবার, ১১ মে, ২০১৩

US Navy's Ion Tiger drone leans on liquid hydrogen for longer-lasting spy flight

Ion Tiger leans on liquid hydrogen for recordbreaking endurance flight

The US Navy's quieter way to spy, the Ion Tiger, just bested its own 2009 flight record with a key assist from liquid hydrogen. The unmanned aerial vehicle had previously relied on 5000-psi compressed hydrogen for fuel, but for its latest flight test the Naval Research team swapped that out for a new cryogenic tank and delivery system that relies on the liquid stuff; a choice made for the element's increased density. With that one significant change in place, the craft was able to outperform its last endurance run of 26 hours and two minutes by almost double, lasting 48 hours and one minute in a flight made mid-April. Spying: it's not only good for the government, it's good for the environment, too.

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Source: US Naval Research Laboratory

Source: http://www.engadget.com/2013/05/10/us-navy-ion-tiger-drone-record-flight/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Patients should have right to control genomic health information, experts say

May 9, 2013 ? Doctors should not have the right or responsibility to force-feed their patients with genomic information about their future health risks, according to bioethicists writing on May 9 in Trends in Biotechnology, a Cell Press publication. They write in response to controversial recommendations from the American College of Medical Genetics and Genomics (ACMG) on the reporting of incidental findings in clinical genome sequencing.

"A lot of people in this field would agree that no one has a right to withhold your health information from you," said Megan Allyse from the Stanford University Center for Biomedical Ethics. "But it's problematic to suggest the inverse: that the medical system should give you information you didn't ask for and don't want. No one should be able to interfere with your ability to accept or decline access. We think that's where these recommendations are problematic, because they do suggest that your physician should interfere in that decision by essentially saying, 'You have to accept this information.' And there is certainly evidence that some people do not want information about long-term health risks, especially in children."

The ACMG recommendations were prompted by the increasing use of genome sequencing in medical care. A challenge in sequencing whole genomes or exomes (protein-coding sequences only) is the sheer quantity of information that results. For instance, a patient may undergo sequencing in an effort to individualize their cancer therapy, but their genome sequence might contain information about their risk of developing Alzheimer's disease in old age. The questions are these: Should patients receive those "incidental findings" or not? And who decides?

The ACMG recommends that anyone undergoing genome sequencing for any reason should be tested for a list of clinically actionable conditions, including predispositions to various forms of cancer and to cardiomyopathy (but not to Alzheimer's disease). Furthermore, the recommendations are that physicians have a duty to then pass that information on to the patient, like it or not.

Not only would such an approach to medicine be a challenge for patient autonomy, but it would also be costly, the bioethicists say.

"It's not clear how those costs would be passed along, either to insurers or to patients themselves," Allyse said. "For the moment, from a patient perspective, the affected population is pretty small, because few people currently undergo whole-genome sequencing. But there are definitely signs that this practice is growing, especially in cancer diagnosis, and so we can envision that this issue of how to define and report incidental findings is likely to affect more and more people in the future. The issue of cost will of course affect any patient who has limited resources -- along with the hospitals, insurance companies, and government programs that pay for much of the care patients receive."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/ettsTf9Qb8w/130509123412.htm

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First Gravity Trailer: In Space, Silence Is Scarier Than Aliens

The thought of being ditched at sea isn't as terrible as being left behind in space. At least when you compare the trailers for Open Water and Alfonso Cuar?n's latest, Gravity. The synopsis for this space odyssey goes something like this:

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Oda68IDWQUY/the-trailer-for-gravity-is-breathtakingly-scary-499801470

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শুক্রবার, ১০ মে, ২০১৩

Myth killer: iPad magnet effect on defibrillators wasn't "discovered" by a 14-year-old

Those magnets in every iPad that allow the Smart Cover and Smart Case to attach securely have the ability to accidentally shut off implanted heart defibrillators if the iPad happens to be lying on the patient's chest. According to a Bloomberg news report yesterday, that discovery was made by Gianna Chien, a 14-year-old high school freshman who presented the results of her science fair project to doctors at a meeting of the Heart Rhythm Society in Denver yesterday.

Well, to be fair, Chien probably just read the iPad user guide, where the warning is plainly written:

iPad has magnets along the left edge of the device and on the right side of the front glass, which may interfere with pacemakers, defibrillators, or other medical devices. The iPad Smart Cover and iPad Smart Case also contain magnets. Maintain at least 6 inches (approximately 15 cm) of separation between your pacemaker or defibrillator and iPad, the iPad Smart Cover, or the iPad Smart Case.

Strong magnets (and not just those on an iPad) can affect defibrillators in several ways -- first, they can put the devices into a test mode that increases the heart rate depending on how much battery life is left in the defibrillator. Second, the defibrillators are designed to be shut off by magnets as a safety precaution. The iPad that Chien used was an iPad 2, which triggered the test mode in 30 percent of patients who put the tablet onto their chest.

While the Bloomberg article and headline provided some titillating reading, Chien didn't "discover" anything. Instead, the 14-year-old and her cardiac electrophysiologist father Walter just used 26 volunteers to test how commonplace the iPad magnet effect is. If Chien should be lauded for anything, it's waking the public up to actually reading those user guides and safety warnings that we all ignore on a regular basis.

In the meantime, if you have a defibrillator or pacemaker implant, don't put the iPad on your chest. Ever.


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Source: http://www.tuaw.com/2013/05/10/myth-killer-ipad-magnet-effect-on-defibrillators-wasnt-discov/

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Zachary Quinto picks his creepiest 'AHS' scene

TV

12 hours ago

Image: Zachary Quinto

Bravo

Zachary Quinto talks about what he thinks was the creepiest "AHS" scene he's had to do.

If Spock were capable of expressing emotion, he would be horrified by the characters Zachary Quinto has played in "American Horror Story."

Stopping by "Watch What Happens Live" as part of his promotional tour for the new "Star Trek Into Darkness" flick, in which the actor reprises his role as Spock, Quinto cheerfully fielded questions from fans.

When one caller asked him to name the creepiest scene he's filmed for "AHS," he recounted a particularly uncomfortable moment from season two.

In the "Asylum" scene, his sadistic psychiatrist Oliver Thredson ordered his lesbian patient Lana Winters to engage in an unusual method to "cure" her of her homosexuality.

"The weirdest scene I had to film was with my great friend Sarah Paulson. I was doing this aversion therapy ..." he said, laughing along with host Andy Cohen and fellow guest Alyson Hannigan. "It was really weird because we've been friends for a long time."

Fans of the creepy FX series likely know exactly which non-family-friendly scene the actor was describing.

"AHS" is full of eyebrow-raising moments, but Quinto spent half a year missing most of his bushy facial feature.

"For seven months I had to shave them," he grumbled good-naturedly about his "Star Trek" character's angled eyebrows. "It wasn't a good look for me. There was waxing, there was shaving. I (wore) a lot of glasses and hats."

Source: http://www.today.com/entertainment/zachary-quinto-picks-his-creepiest-american-horror-story-scene-1C9858217

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Video: Wednesday's Market Roadmap

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Source: http://www.nbcnews.com/video/cnbc/51816365/

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(AUDIO) Ronde Barber On Rome

(Photo by Kevin C. Cox/Getty Images)

(Photo by Kevin C. Cox/Getty Images)

Today on 98.7 The Fan, Jim Rome was joined by Ronde Barber to talk about his illustrious career. Ronde covered his time in Tampa, his place historically in the NFL, and what he will do with his life post football.? Barber says that a career in broadcasting could be in his future on a national level.

Tune in to The Jim Rome show every weekday from 12p-3p before Booger and Rich on Sports Radio 98.7 The Fan.

  • Ronde Barber w/Jim Rome 5/9/13
  • Jim Rome

Source: http://tampa.cbslocal.com/2013/05/09/audio-ronde-barber-on-rome/

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বৃহস্পতিবার, ৯ মে, ২০১৩

New insights into Ebola infection pave the way for much-needed therapies

Wednesday, May 8, 2013

The Ebola virus is among the deadliest viruses on the planet, killing up to 90% of those infected, and there are no approved vaccines or effective therapies. A study published by Cell Press on May 7th in the Biophysical Journal reveals how the most abundant protein making up the Ebola virus?viral protein 40 (VP40)?allows the virus to leave host cells and spread infection to other cells throughout the human body. The findings could lay the foundation for the development of new drugs and strategies for fighting Ebola infection.

"Little research is available on how the Ebola virus buds from the plasma membrane of human cells," says senior study author Robert Stahelin of Indiana University School of Medicine. "By shedding light on this process, our study will help us to identify potential drug candidates that could interfere with this step in the viral life cycle."

The Ebola virus is made up of seven proteins, including VP40, which plays a key role in enabling the virus to leave host cells and infect other cells in the human body. Past studies have shown that a part of VP40 called the C-terminal domain penetrates the plasma membrane surrounding host cells. But until now, it was not known exactly how VP40 binds to the plasma membrane to allow the virus to escape host cells.

To address this question, Stahelin and his team made vesicles designed to mimic the plasma membrane of host cells and exposed these vesicles to VP40. Observing their interactions under the microscope, they found that VP40's C-terminal domain penetrates more than halfway into one layer of the vesicles. VP40 also caused the vesicle membranes to bend into the shape of the Ebola virus, paving the way for its escape. When the researchers mutated the C-terminal domain of VP40, the protein was much less effective at binding to and bending membranes and forming virus-like particles that could escape from host cells.

Altogether, the findings reveal how VP40's C-terminal domain allows the Ebola virus to spread infection. "Currently, we are trying to find small molecules that can inhibit VP40 interactions with the plasma membrane," Stahelin says. "This effort could lead to the discovery of potential drug candidates that could form the basis of much-needed therapies for this deadly virus."

###

Biophysical Journal, Soni et al.: "The Ebola Virus Matrix Protein Deeply Penetrates the Plasma Membrane: An Important Step in Viral Egress."

Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128168/New_insights_into_Ebola_infection_pave_the_way_for_much_needed_therapies

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The Weirdest Thing on the Internet Tonight: Take Me to The Fog

No matter how advanced the invading alien culture, rest assured that humanity will find a way to fight back?be it the bacteria from War of the Worlds, Jeff Goldblum from Independence Day, or a pipe rip of the sticky icky from Stephen J Mitchell's awesome stop motion short, Take Me to the Fog.

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/5-ou4HC9zz4/the-weirdest-thing-on-the-internet-tonight-take-me-to-496204939

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Oldest 'dome-headed' dinosaur discovered in Canada

A newly discovered dome-headed, dog-size dinosaur suggests that small dinos were more diverse than paleontologists have realized.

?

The dinosaur, discovered in Alberta, Canada, is named Acrotholus audeti; Acrotholus means "high dome," as the new dinosaur was a pachycephalosaur, a group known for their thick, bony skulls. The new specimen is the oldest pachycephalosaur ever found in North America, and rivals the oldest specimen in the world, scientists report today (May 7) in the journal Nature Communications.

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"Acrotholus provides a wealth of new information on the evolution of bone-headed dinosaurs. Although it is one of the earliest known members of this group, its thickened skull dome is surprisingly well-developed for its geological age," study researcher David Evans, the curator of vertebrate paleontology at the Royal Ontario Museum, said in a statement. [Gallery: Gorgeous Dinosaur Fossils]

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The dinosaur roamed in what is now Alberta about 85 million years ago. That's 5 million years before the next known pachycephalosaur specimen found in North America. Another pachycephalosaur from Mongolia is approximately the same age as the new species.

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Paleontologists found fragments of the animal's skull ? more than 2 inches (10 centimeters) thick ? on the ranch of Roy Audet, whose surname gives the new species the second half of its scientific name.

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Given the diversity of small animals in modern times, researchers would expect to see that ancient ecosystems had a large share of tiny dinosaurs. But dinosaurs that weighed less than about 220 lbs. (100 kilograms) don't fossilize well. Any bones that weren't immediately scattered or weathered into dust were often washed away from the death site, leading to jumbled, confused fossil sites. Big beasts such as long-necked, bus-sized sauropods are easier to unearth.

?

Most pachycephalosaurs weighed less than 88 lbs. (40 kg), or smaller than a well-fed Labrador retriever. But compared with other dinosaurs of that size, they are likely better represented in the fossil record, because their enormously thick skulls weather time and the elements better than the craniums of more delicate dinosaur species.

?

Even so, Evans and his colleagues found that pachycephalosaur diversity has likely been underestimated by as much as a factor of five. That means the diversity of other small dinosaurs is even more unknown.

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"We can predict that many new small dinosaur species like Acrotholus are waiting to be discovered by researchers willing to sort through the many small bones that they pick up in the field," study researcher Michael Ryan, who curates vertebrate paleontology at the Cleveland Museum of Natural History, said in a statement.

?

The Acrothoulus fossils are set to go on display at the Royal Ontario Museum this month.

?

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Related on LiveScience and MNN:

This story was originally written for LiveScience and was republished with permission here. Copyright 2013 LiveScience, a TechMediaNetwork company.

Source: http://www.mnn.com/earth-matters/animals/stories/oldest-dome-headed-dinosaur-discovered-in-canada

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শুক্রবার, ২৬ এপ্রিল, ২০১৩

Ice tubes in polar seas -- 'brinicles' or 'sea stalactites' -- provide clues to origin of life

Apr. 24, 2013 ? Life on Earth may have originated not in warm tropical seas, but with weird tubes of ice -- sometimes called "sea stalactites" -- that grow downward into cold seawater near Earth's poles, scientists are reporting. Their article on these "brinicles" appears in ACS' journal Langmuir.

Bruno Escribano and colleagues explain that scientists know surprisingly little about brinicles, which are hollow tubes of ice that can grow to several yards in length around streamers of cold seawater under pack ice. That's because brinicles are difficult to study. The scientists set out to gather more information on the topic with an analysis of the growth process of brinicles.

They are shown to be analogous to a "chemical garden," a standby demonstration in chemistry classes and children's chemistry sets, in which tubes grow upward from metal salts dropped into silicate solution. But brinicles grow downward from the bottom of the ice pack.

The analysis concluded that brinicles provide an environment that could well have fostered the emergence of life on Earth billions of years ago, and could have done so on other planets. "Beyond Earth, the brinicle formation mechanism may be important in the context of planets and moons with ice-covered oceans," the report states, citing in particular two moons of Jupiter named Ganymede and Callisto.

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The above story is reprinted from materials provided by American Chemical Society.

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Journal Reference:

  1. Julyan Cartwright, Bruno Escribano, Diego L. Gonz?lez, Claro Ignacio Sainz-Diaz, idan tuval. Brinicles as a case of inverse chemical gardens. Langmuir, 2013; : 130403173604005 DOI: 10.1021/la4009703

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/DaSQJwKHSz4/130424112316.htm

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বৃহস্পতিবার, ২৫ এপ্রিল, ২০১৩

Bangladesh collapse factories ignored evacuation

Bangladeshi people gather as rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

Bangladeshi people gather as rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

In this image taken from AP video, garment worker Mohammad Altab moans to rescuers for help while trapped between concrete slabs and next to two corpses in a garment factory that collapsed Wednesday in Savar, near Dhaka, Bangladesh, Thursday, April 25, 2013. Deep cracks visible in the walls of the Bangladesh garment building had compelled police to order it evacuated a day before it collapsed, officials said Thursday. More than 200 people were killed when the eight-story building splintered into a pile of concrete because factories based there ignored the order and kept more than 2,000 people working. (AP Photo/AP video)

Relatives cry as rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete on Wednesday. (AP Photo/A.M.Ahad)

Bangladesh rescuers look for survivors and victims at the site of a building that collapsed Wednesday in Savar, near Dhaka, Bangladesh,Thursday, April 25, 2013. By Thursday, the death toll reached at least 194 people as rescuers continued to search for injured and missing, after a huge section of an eight-story building that housed several garment factories splintered into a pile of concrete. (AP Photo/A.M.Ahad)

Rescue workers use clothing to lower down survivors from the site of a building that collapsed in Savar, near Dhaka, Bangladesh, Wednesday, April 24, 2013. An eight-story building housing several garment factories collapsed near Bangladesh?s capital on Wednesday, killing dozens of people and trapping many more under a jumbled mess of concrete. Rescuers tried to cut through the debris with earthmovers, drilling machines and their bare hands. (AP Photo/A.M.Ahad)

(AP) ? Deep cracks visible in the walls of a Bangladesh garment building had compelled police to order it evacuated a day before it collapsed, officials said Thursday. More than 230 people were killed when the eight-story building splintered into a pile of concrete because factories based there ignored the order and kept more than 2,000 people working.

Wednesday's disaster in the Dhaka suburb of Savar is the worst ever for Bangladesh's booming and powerful garment industry, surpassing a fire less than five months earlier that killed 112 people. Workers at both sites made clothes for major brands around the world; some of the companies in the building that fell say their customers include retail giants such as Wal-Mart.

Hundreds of rescuers, some crawling through the maze of rubble in search of survivors and corpses, worked through the night and into Thursday amid the cries of the trapped and the wails of workers' relatives gathered outside the building, called Rana Plaza. It housed numerous garment factories and a handful of other companies.

An Associated Press cameraman who went into the rubble with rescue workers spoke briefly to a garment worker pinned face down in the darkness between concrete slabs and next to two corpses. Mohammad Altab pleaded for help, but they were unable to free him.

"Save us, brother. I beg you, brother. I want to live," Altab moaned. "It's so painful here ... I have two little children."

Another survivor, whose voice could be heard from deep in the rubble, wept as he called for help.

"We want to live, brother. It's hard to remain alive here. It would have been better to die than enduring such pain to live on. We want to live. Please save us," the man cried.

After the cracks were reported in the walls of Rana Plaza on Tuesday, managers of a local bank that also had an office in the building evacuated their workers. The garment factories, though, kept working, ignoring the instructions of the local industrial police, said Mostafizur Rahman, a director of that paramilitary police force.

The Bangladesh Garment Manufacturers and Exporters Association had also asked the factories to suspend work starting Wednesday morning, hours before the collapse.

"After we got the crack reports, we asked them to suspend work until further examination, but they did not pay heed," said Atiqul Islam, the group's president.

On Thursday morning, the odor of rotting bodies wafted through holes cut into the building. Bangladesh's junior minister for home affairs, Shamsul Haque, said that by late Thursday morning 2,000 people had been rescued from the wreckage.

Brig. Gen. Mohammed Siddiqul Alam Shikder, who is overseeing army rescue teams, said the death toll had climbed to 238 by Thursday evening.

Dozens of bodies, their faces covered, were laid outside a local school building so relatives could identify them. Thousands of workers' relatives gathered outside the building, waiting for news, and thousands of garment workers from nearby factories took to the streets across the industrial zone in protest.

Shikder said rescue operations were progressing slowly and carefully to save as many people as possible.

He said rescue teams were standing by with heavy equipment and would "start bulldozing the debris once we get closer to the end of the operation. But now we are careful."

He also said the huge crowd that remained at the collapse site Thursday was interfering with getting more rescuers to the scene.

"We are ready with about 1,000 soldiers and rescue workers from other departments. But a huge crowd is obstructing our effort," he said.

Thousands of workers from the hundreds of other garment factories in the Savar industrial zone took to the streets to protest the factory collapse and poor safety standards for the country's garment workers.

Television reports said that hundreds of protesting workers also clashed with police in Dhaka and the nearby industrial zone of Ashulia. It was not immediately clear whether there were any injuries in those clashes.

The garment manufacturers' group said the factories in Rana Plaza employed 3,122 workers, but it was not clear how many were in the building when it collapsed.

Searchers worked through the night to probe the jumbled mass of concrete with drills or their bare hands, passing water and flashlights to people pinned inside.

"I gave them whistles, water, torchlights. I heard them cry," said fire official Abul Khayer late Wednesday, as he prepared to work late into the night.

Abdur Rahim, an employee who worked on the fifth floor, said he and his co-workers had gone inside Wednesday morning despite the cracks in the building, after a factory manager gave assurances that it was safe. About an hour later, the building collapsed. The next thing Rahim remembered was regaining consciousness outside.

Abdul Halim, an official with the engineering department in Savar, said the owner was originally allowed to construct a five-story building but added another three stories illegally.

On a visit to the site, Home Minister Muhiuddin Khan Alamgir told reporters the building had violated construction codes and that "the culprits would be punished."

Local police chief Mohammed Asaduzzaman said police and the government's Capital Development Authority have filed separate cases of negligence against the building owner. Bangladesh's High Court also asked the owner of the building and the heads of the garment factories to appear before it on April 30 to explain their role.

Habibur Rahman, police superintendent of the Dhaka district, identified the building owner as Mohammed Sohel Rana, a local leader of the ruling Awami League's youth front. Rahman said police were looking for the owners of the garment factories.

Among the garment makers in the building were Phantom Apparels, Phantom Tac, Ether Tex, New Wave Style and New Wave Bottoms. Altogether, they produced several million shirts, pants and other garments a year.

The New Wave companies, according to their website, make clothing for major brands including North American retailers The Children's Place and Dress Barn, Britain's Primark, Spain's Mango and Italy's Benetton. Ether Tex said Wal-Mart, the world's biggest retailer, was one of its customers.

Primark acknowledged it was using a factory in Rana Plaza, but many other retailers distanced themselves from the disaster, saying they were not involved with the factories at the time of the collapse or had not recently ordered garments from them.

Benetton said in an email to The Associated Press that people involved in the collapse were not Benetton suppliers. Wal-Mart said it was investigating and Mango said it had only discussed production of a test sample of clothing with one of the factories.

The November factory fire that killed 112 people drew international attention to working conditions in Bangladesh's $20 billion-a-year textile industry. There were calls by labor activists, manufacturers, the government and major retailers for improved safety standards, but so far there has been little progress. The country has about 4,000 garment factories and exports clothes to leading Western retailers, and industry leaders hold great influence in the South Asian nation.

Bangladesh's garment industry was the third-largest in the world in 2011, after China and Italy. It has grown rapidly over the past decade, a boom fueled by some of the lowest labor costs in the world. The national minimum wage, which was doubled in 2010, stands at $38 per month.

The Tazreen factory that caught fire in November lacked emergency exits, and its owner said only three floors of the eight-story building were legally built. Surviving employees said gates had been locked and managers had told them to go back to work after the fire alarm went off.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-25-AS-Bangladesh-Building-Collapse/id-4736c258111e40f1a26b8dca1e3d9a16

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Fonda to add prints by dad's at Chinese Theatre

LOS ANGELES (AP) ? Jane Fonda is planning to shed a few tears on Saturday.

That's when the 75-year-old Oscar winner will place her hand and footprints next to her father's in the concrete shrine to celebrity outside Hollywood's Chinese Theatre. Then she'll present a special screening of the film she made with her dad, 1981's "On Golden Pond." The cement and cinematic tribute is part of the 2013 TCM Classic Film Festival, which is honoring Jane Fonda.

"I am very, very excited," Fonda said in an interview this week. "I thought probably I would die and this would never happen. I'm just really thrilled that it actually is happening and not only that, but I get to put my hand and footprints right next to my father. ... I'm just so happy I'll probably cry."

The honor inspired Fonda to reflect on her career, which hasn't slowed since she returned to acting in 2005 after a 15-year hiatus.

"I've made some really good films. There's also a lot of films I wish I could do over again," she said. "But I've been lucky: I've worked with some great directors, and I feel like I'm still a work in progress as an actor. I feel like I'm still learning."

After her guest-starring stint on "The Newsroom," she's more interested than ever in television.

"I'd love to have a television series of my own," Fonda said. "I'm hoping that might happen."

A fitness pioneer, Fonda continues to focus on health and wellness with a series of videos aimed at older exercisers. She also inspired countless Oscar watchers earlier this year with her fitted, bright yellow gown, and she serves as L'Oreal's oldest spokeswoman.

"When you're younger, you don't have to put so much time into it, but also I didn't care that much. I was an activist and I didn't think so much about how I appeared," she said. "As I've gotten older, I've paid more attention to how I dress, how I look, what makeup I use, what skincare products I use... I guess one reason that I put more effort into looking good now is because I think it gives hope to other women. It takes the edge off the fear that young people have of getting older."

The wisdom and openness that come with aging are easy to wear well, and Fonda said she's happier now than ever.

"This event that's coming up where I get to put my hand and shoeprints next to my dad in front of the Chinese Theatre, it's coming at a very happy time in my life," Fonda said, "and making it even happier."

___

Follow AP Entertainment Writer Sandy Cohen on Twitter: www.twitter.com/APSandy.

___

Online:

http://filmfestival.tcm.com

Source: http://news.yahoo.com/fonda-add-prints-dads-chinese-theatre-140051305.html

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AMD Radeon HD 7990 review roundup: fast, quiet, but no world beater

Now that the veil has been lifted from the AMD Radeon HD 7990, it's time for the usual enthusiast review sites to reveal their thoughts -- and benchmarks -- on the latest graphics card from Sunnyvale. As we've mentioned, the 7990 has effectively two 7970 GPUs on board, promising over 8 TFLOPS of power and the chops to handle full 4K resolution under maximum settings. However, it's a pricey little thing at around $1,000, which doesn't set it too far away from the competition and its unique cooling system means an airy case is a must. What do our sample of reviewers think? Find out in our roundup after the break.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/iqj4mCJYBNw/

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Many Who Got Thyroid Cancer After Chernobyl Still Alive: Study ...

chernobyl Many Who Got Thyroid Cancer After Chernobyl Still Alive: Study

WEDNESDAY, April 24 (HealthDay News) ? Many people who were children and teens when they developed thyroid cancer after the Chernobyl nuclear disaster in 1986 are now in total or nearly complete remission, a new study indicates.

The finding is good news for people exposed to radiation from the 2011 Fukushima accident in Japan and other victims of nuclear disasters, the researchers said.

Following the explosion and fire at the Chernobyl nuclear plant in Ukraine, there was a spike in the number of children and teens diagnosed with thyroid cancer in Ukraine, Belarus and western areas of Russia.

This study looked at the outcomes of nearly 250 Belarusian children and teens who were diagnosed with thyroid cancer after the disaster and underwent surgery and radioiodine therapy. The researchers found that 64 percent of the patients are in complete remission and 30 percent are in nearly complete remission of their cancer.

One patient died of lung fibrosis, a side effect of cancer treatment. Only two had thyroid cancer recurrences, according to the study, which was published online April 24 in the Journal of Clinical Endocrinology & Metabolism.

?Even though some patients did not receive optimal treatment initially, the vast majority went into remission after receiving state-of-the-art radioiodine treatment and follow-up care,? study author Dr. Christoph Reiners, of the University of Wurzburg, in Germany, said in a journal news release.

?Many patients recovered from advanced cancers,? he said. ?Of this group, 97 percent had cancer spread to the lymph nodes, and 43 percent had cancer metastasize in the lungs.?

The findings suggest that victims of more recent nuclear disasters face a lower risk of developing advanced-stage thyroid cancer.

?Although people fear a similar thyroid cancer ?epidemic? will affect Japan, the quick actions taken to evacuate or shelter residents and ban potentially contaminated foods following the Fukushima accident greatly reduced the risks of children developing radiation-induced thyroid cancer,? Reiners said.

?In addition, Chernobyl has taught us how important it is to have at-risk children and adolescents screened for thyroid cancer to catch any cases in their early stages,? he said. ?Because public health authorities are aware of the risks, screening programs for children from the Fukushima area already have been initiated.?

More information

The American Cancer Society has more about thyroid cancer.

HEALTHDAY Web XSmall Many Who Got Thyroid Cancer After Chernobyl Still Alive: Study

Source: http://news.health.com/2013/04/24/many-who-got-thyroid-cancer-after-chernobyl-still-alive-study/

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শুক্রবার, ৫ এপ্রিল, ২০১৩

Make Your Over-The-Ear Headphones More Comfortable With Some Foam Tubing

Make Your Over-The-Ear Headphones More Comfortable With Some Foam TubingIf you wear headphones for an extended amount of time, chances are you'll start to feel some discomfort around your ears. This quick hack from the folks at WonderHowTo is a great way to make your headphones more comfortable for extended wear.

All you need to do is cut a length of backer rod?the thin foam tubing used before caulking?and use it to line the inside of your headphones as padding. Audiophiles should note that even a small, unobtrusive change like this can alter how your headphones sound, so your mileage may vary. However, if you've got a pair of cheaper headphones you just want to make more comfortable, this is probably worth a shot. You might also want to check out these further tricks for making your headphones more comfortable or our top 10 headphone hacks.

How to Make Your Headphones More Comfortable with Caulk Backer Rods | WonderHowTo

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/FvY5xqr08O0/make-your-over+the+ear-headphones-more-comfortable-with-some-foam-tubing

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Dismal US jobs report, Iran talks weigh on oil

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Source: http://news.ph.msn.com/business/dismal-us-jobs-report-iran-talks-weigh-on-oil

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