মঙ্গলবার, ১৪ মে, ২০১৩

BlackBerry announces new Android support in enterprise management suite

BlackBerry Live

The better part of the CrackBerry crew are at BlackBerry Live 2013 this week, and there was a bit of news for Android fans amid the general session. BlackBerry Enterprise Service 10.1 was announced, which includes support for Android devices. That means your IT guy can roll out apps and lock down BlackBerry devices throughout the company just as easily as it can with any Android devices. 

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Source: http://feedproxy.google.com/~r/androidcentral/~3/rcIT8ot67JU/story01.htm

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How does Benghazi affect Clinton? (CNN)

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সোমবার, ১৩ মে, ২০১৩

Tesla Motors: Lots of buzz. Is it warranted?

Tesla Motors is a bright spot?amid high-profile, federally-funded electric car flops. Tesla Founder Musk has found a way to bring high-tech pizzazz to a 'green' car drawing comparisons to Steve Jobs and Apple.

By David J. Unger,?Correspondent / May 10, 2013

Tesla Motors CEO Elon Musk speaks at his company's factory in Fremont, Calif. Tesla is among perhaps only a handful of companies that have changed the way consumers think about alternative energy.

Noah Berger/Reuters/File

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Tesla Motors had a good week.

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Why It Matters

Energy: The transportation sector consumes 70 percent of the oil used in the US. EVs can held diminish that reliance.?

Environment: Depending on where their electricity comes from, EVs could reduce greenhouse gas emissions.

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The luxury electric carmaker posted its first profit late Wednesday. The next day, Tesla's Model S tied for Consumer Reports? highest testing score ever. Wall Street rejoiced, pushing shares of Tesla up 24 percent on the news.

Tesla Motors is a bright spot?amid high-profile, federally-funded electric car flops. CEO Elon Musk's innovative approach to carmaking suggests the energy industry can benefit from borrowing a page from the tech sector's playbook.

The two sectors have borne some resemblence of late. New computer software has changed the way we look for oil. Smart thermostats are saving on residential energy consumption. The lithium-ion batteries that have powered our consumer electronics for a decade, are beginning to transform the way we fuel our cars. ?

But if you're expecting the electrical grid to transform as quickly as the superconductor, you may be disappointed.?

Magia Maledicto

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Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/vwmCbGJoHfg/viewtopic.php

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রবিবার, ১২ মে, ২০১৩

'Gatsby' gives 'Iron Man 3' a run for its money

This film publicity image released by Warner Bros. Pictures shows Leonardo DiCaprio as Jay Gatsby in a scene from "The Great Gatsby." (AP Photo/Warner Bros. Pictures)

This film publicity image released by Warner Bros. Pictures shows Leonardo DiCaprio as Jay Gatsby in a scene from "The Great Gatsby." (AP Photo/Warner Bros. Pictures)

This film publicity image released by Disney-Marvel Studios shows Robert Downey Jr., left, as Tony Stark/Iron Man and Gwyneth Paltrow as Pepper Potts in a scene from "Iron Man 3." (AP Photo/Disney, Marvel Studios)

(AP) ? Gatsby looks almost as great as a superhero at the weekend box office.

Leonard DiCaprio's "The Great Gatsby" partied like it was the Roaring '20s with a $51.1 million debut that made it a surprisingly strong runner-up to comic-book blockbuster "Iron Man 3."

Studio estimates Sunday put "Gatsby" at No. 2 behind Robert Downey Jr.'s superhero sequel, which pulled in $72.5 million domestically to raise its total to $284.9 million after just 10 days in U.S. theaters.

With an additional $89.3 million in its third weekend overseas, "Iron Man 3" lifted its international total to $664.1 million and its worldwide haul to $949 million.

"The Great Gatsby" far exceeded expectations by distributor Warner Bros. of a $35 million to $40 million opening weekend.

Director Baz Luhrmann's 3-D adaptation of the F. Scott Fitzgerald classic was a rare box-office smash for films aimed at older adults during the youth-minded summer season. According to Warner Bros., viewers over 25 made up 69 percent of the film's audience.

"It answers the question that you and I hear all the time from people over 50, 'There's nothing for me to see,'" said Dan Fellman, the studio's head of distribution. "While every studio has the $200 million tentpoles in the marketplace, you still have those who feel that it's not directed at them, which is true. So that's why I think counterprogramming like this is very important."

The weekend's other new wide release, Lionsgate's romantic comedy "Peeples," flopped at No. 4 with just $4.9 million. Produced by Tyler Perry, the movie stars Craig Robinson and Kerry Washington in a meet-the-parents-style farce.

Getting a head start on its domestic launch Friday, "Star Trek: Into Darkness" opened with $31.7 million in seven international markets. Its overseas debut included $13.3 million in Great Britain, $7.6 million in Germany and $5.5 million in Australia.

Starring DiCaprio in the title role as 1920s mystery millionaire Jay Gatsby, the latest Fitzgerald update co-stars Carey Mulligan as his lost love and Tobey Maguire as the friend chronicling their doomed romance.

It was by far the biggest debut ever for filmmaker Luhrmann, whose previous best was $14.8 million for "Australia." In just one weekend, "The Great Gatsby" nearly matched the $57.4 million domestic haul that Luhrmann's top-grossing film, the musical "Moulin Rouge!", managed in its entire run.

"Gatsby" also gave DiCaprio his second-biggest debut, behind the $62.8 million take for "Inception."

The film's success follows a bumpy road to theaters. Originally scheduled for release last December, Warner Bros. pushed it back to summer to give Luhrmann more time to finish his elaborate visual spectacle.

How well the film holds up in coming weeks depends on word-of-mouth from fans. Reviews for "The Great Gatsby" have been so-so, with many critics saying it sacrifices drama and substance for style and dazzle, including Lurhmann's elaborate party scenes backed by a contemporary soundtrack featuring Jay-Z, Beyonce and Lana Del Rey.

"Iron Man 3" was down a steep 58 percent from its opening weekend haul, no surprise given that its $174.1 million domestic debut was the second-biggest ever. The only film to do more business was Downey and company's ensemble adventure "The Avengers," which topped $200 million in its premiere last year.

"The Avengers" held up better in its second weekend with $103.1 million, a drop of only 50 percent. But "Iron Man 3" is on its way to becoming the biggest solo superhero hit worldwide and the second-biggest comic-book adaptation, behind the $1.5 billion "Avengers" payday.

"This is on a trajectory like no other individual superhero movie we've ever seen," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "In less than three weeks, this thing is honing in on a billion dollars. It's just a testament to the incredible popularity of this character."

The movie already has far surpassed the franchise best of $624 million worldwide for "Iron Man 2."

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers are also included. Final domestic figures will be released Monday.

1. "Iron Man 3," $72.5 million ($89.3 million international).

2. "The Great Gatsby," $51.1 million.

3. "Pain and Gain," $5 million.

4. "Peeples," $4.9 million.

5. "42," $4.7 million.

6. "Oblivion," $3.9 million ($11.7 million international).

7. "The Croods," $3.6 million ($17.3 million international).

8. "The Big Wedding," $2.5 million ($2 million international).

9. "Mud," $2.4 million.

10. "Oz the Great and Powerful," $802,000.

___

Estimated weekend ticket sales at international theaters (excluding the U.S. and Canada) for films distributed overseas by Hollywood studios, according to Rentrak:

1. "Iron Man 3," $89.3 million.

2. "Star Trek: Into Darkness," $31.7 million.

3. "The Croods," $17.3 million.

4. "Oblivion," $11.7 million.

5. "Les Profs," $3.7 million.

6. "Boomerang Family," $3.6 million.

7. "Scary Movie 5," $2.7 million.

8. "Evil Dead," $2.6 million.

9. "Hanni and Nanni 3," $2.3 million.

10. "The Big Wedding," $2 million.

___

Online:

http://www.hollywood.com

http://www.rentrak.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-05-12-Box%20Office/id-ab41d43b4c5b4bd2b2fee9d9a48c0091

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Take that, iPad mini: Retina display Nexus 7 at Google I/O says analyst

While Apple fans are waiting for an iPad mini with improved screen, Android enthusiasts may see the Nexus 7 get its own Retina display next week. KGI Securities?analyst?Ming-Chi Kuo penned a research note that AppleInsider read and Kuo expects Google?s small slate to gain a 1920 x 1200 display at Google?s I/O Developer event, which takes place May 15 to May 17.

Kuo?s expectations aren?t that different from earlier Reuters reports,?whose sources in April indicated a high-resolution display, faster processor and doubling of device memory to 2 GB coming to the next model Nexus 7. Reuters suggested a 1920 x 1080 panel at 315 pixels per inch, while Kuo figures a 1920 x 1200 display at 323 PPI.

A Qualcomm APQ8064 chip will power the updated tablet, says Kuo, which is the same Snapdragon 600 currently used in the LG Optimus G Pro, Samsung Galaxy S 4 and HTC One smartphones.?Wireless charging, an LTE option, 5 megapixel rear camera and Android 4.3 are also expected by the analyst.

These specifications sound right to me and I do expect Google to introduce a refreshed Nexus 7 at its developer event. I don?t think, however, that Google will be able to maintain the $199.99 current starting price for an updated Nexus 7. Even if the device comes in at a $249 to $299 range for a base Wi-Fi model, it?s less than Apple?s non-Retina iPad mini, which is $329. I still give some advantage to the iPad line, however, as I see more applications optimized for higher-resolution screens on iOS than on Android.

Source: http://gigaom.com/2013/05/10/take-that-ipad-mini-retina-display-nexus-7-at-google-io-says-analyst/

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Today in History

Today is Sunday, May 12, the 132nd day of 2013. There are 233 days left in the year. This is Mother's Day.

Today's Highlights in History:

On May 12, 1943, during World War II, Axis forces in North Africa surrendered. The two-week Trident Conference, headed by President Franklin D. Roosevelt and British Prime Minister Winston Churchill, opened in Washington.

On this date:

In 1780, during the Revolutionary War, the besieged city of Charleston, S.C., surrendered to British forces.

In 1870, an act creating the Canadian province of Manitoba was given royal assent, to take effect in July.

In 1922, a 20-ton meteor crashed near Blackstone, Va.

In 1932, the body of Charles Lindbergh Jr., the kidnapped son of Charles and Anne Lindbergh, was found in a wooded area near Hopewell, N.J.

In 1933, the Federal Emergency Relief Administration and the Agricultural Adjustment Administration were established to provide help for the needy and farmers.

In 1937, Britain's King George VI was crowned at Westminster Abbey; his wife, Elizabeth, was crowned as queen consort.

In 1949, the Soviet Union lifted the Berlin Blockade, which the Western powers had succeeded in circumventing with their Berlin Airlift.

In 1958, the United States and Canada signed an agreement to create the North American Air Defense Command (later the North American Aerospace Defense Command, or NORAD).

In 1963, Betty Miller became the first woman to fly solo across the Pacific Ocean as she landed her Piper Apache in Brisbane, Australia, having left Oakland, Calif., on April 30, making three stopovers along the way.

In 1970, the Senate voted unanimously to confirm Harry A. Blackmun as a Supreme Court justice.

In 1982, in Fatima, Portugal, security guards overpowered a Spanish priest armed with a bayonet who attacked Pope John Paul II. (In 2008, the pope's longtime private secretary revealed that the pontiff was slightly wounded in the assault.)

In 2002, Jimmy Carter arrived in Cuba, becoming the first U.S. president in or out of office to visit since the 1959 revolution that put Fidel Castro in power.

Ten years ago: Suicide bombers attacked foreigners' housing compounds in Riyadh, Saudi Arabia, killing 25 victims. A suicide truck-bomb attack killed at least 60 at a government compound in northern Chechnya. L. Paul Bremer, the new American civilian administrator of Iraq, arrived in Baghdad; coalition forces announced they had taken custody of Dr. Rihab Rashid Taha (TAH'-hah), the Iraqi scientist known as "Dr. Germ." (Taha was later released after no charges were brought.) The Texas House ground to a standstill after 51 Democratic lawmakers left the state in a dispute over a Republican congressional redistricting plan. (The Democrats returned four days later from Oklahoma, having succeeded in killing the bill.)

Five years ago: A devastating earthquake in China's Sichuan province killed some 70,000 people. Nearly 400 workers were arrested in an immigration raid at a kosher meatpacking plant in Postville, Iowa. Irena Sendler, credited with saving some 2,500 Jewish children from the Holocaust, died in Warsaw, Poland, at age 98. Pop artist Robert Rauschenberg died on Captiva Island, Fla, at age 82. Indians second baseman Asdrubal Cabrera turned the 14th unassisted triple play in major league history during the second game of a doubleheader against Toronto. NBC announced that Jimmy Fallon would succeed Conan O'Brien as host of "Late Night."

One year ago: At least 100,000 Spaniards angered by grim economic prospects and the political handling of the international financial crisis turned out for street demonstrations, marking the one-year anniversary of a spontaneous movement that inspired similar protests elsewhere. Miami's LeBron James became the eighth player in NBA history to win the MVP award three times.

Today's Birthdays: Baseball Hall-of-Famer Yogi Berra is 88. Critic John Simon is 88. Composer Burt Bacharach is 85. Actress Millie Perkins is 75. Rhythm-and-blues singer Jayotis Washington is 72. Country singer Billy Swan is 71. Actress Linda Dano is 70. Musician Ian McLagan is 68. Actress Lindsay Crouse is 65. Singer-musician Steve Winwood is 65. Actor Gabriel Byrne is 63. Actor Bruce Boxleitner is 63. Singer Billy Squier is 63. Country singer Kix Brooks is 58. Actress Kim Greist is 55. Rock musician Eric Singer (KISS) is 55. Actor Ving Rhames is 54. Rock musician Billy Duffy is 52. Actor Emilio Estevez is 51. Actress April Grace is 51. Actress Vanessa A. Williams ("Melrose Place") is 50. Country musician Eddie Kilgallon is 48. Actor Stephen Baldwin is 47. Actor Scott Schwartz is 45. Actress Kim Fields is 44. Actress Samantha Mathis is 43. Actress Jamie Luner is 42. Actor Christian Campbell is 41. Actress Rhea Seehorn is 41. Actor Mackenzie Astin is 40. Actress Malin (MAH'-lin) Akerman is 35. Actor Jason Biggs is 35. Actress Emily VanCamp is 27. Actor Malcolm David Kelley is 21. Actors Sawyer and Sullivan Sweeten ("Everybody Loves Raymond") are 18.

Thought for Today: "A mother becomes a true grandmother the day she stops noticing the terrible things her children do because she is so enchanted with the wonderful things her grandchildren do." ? Lois Wyse, American advertising executive, author and columnist (1926-2007).

(Above Advance for Use Sunday, May 12)

Copyright 2013, The Associated Press. All rights reserved.

Source: http://news.yahoo.com/today-history-050206767.html

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শনিবার, ১১ মে, ২০১৩

US Navy's Ion Tiger drone leans on liquid hydrogen for longer-lasting spy flight

Ion Tiger leans on liquid hydrogen for recordbreaking endurance flight

The US Navy's quieter way to spy, the Ion Tiger, just bested its own 2009 flight record with a key assist from liquid hydrogen. The unmanned aerial vehicle had previously relied on 5000-psi compressed hydrogen for fuel, but for its latest flight test the Naval Research team swapped that out for a new cryogenic tank and delivery system that relies on the liquid stuff; a choice made for the element's increased density. With that one significant change in place, the craft was able to outperform its last endurance run of 26 hours and two minutes by almost double, lasting 48 hours and one minute in a flight made mid-April. Spying: it's not only good for the government, it's good for the environment, too.

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Source: US Naval Research Laboratory

Source: http://www.engadget.com/2013/05/10/us-navy-ion-tiger-drone-record-flight/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Patients should have right to control genomic health information, experts say

May 9, 2013 ? Doctors should not have the right or responsibility to force-feed their patients with genomic information about their future health risks, according to bioethicists writing on May 9 in Trends in Biotechnology, a Cell Press publication. They write in response to controversial recommendations from the American College of Medical Genetics and Genomics (ACMG) on the reporting of incidental findings in clinical genome sequencing.

"A lot of people in this field would agree that no one has a right to withhold your health information from you," said Megan Allyse from the Stanford University Center for Biomedical Ethics. "But it's problematic to suggest the inverse: that the medical system should give you information you didn't ask for and don't want. No one should be able to interfere with your ability to accept or decline access. We think that's where these recommendations are problematic, because they do suggest that your physician should interfere in that decision by essentially saying, 'You have to accept this information.' And there is certainly evidence that some people do not want information about long-term health risks, especially in children."

The ACMG recommendations were prompted by the increasing use of genome sequencing in medical care. A challenge in sequencing whole genomes or exomes (protein-coding sequences only) is the sheer quantity of information that results. For instance, a patient may undergo sequencing in an effort to individualize their cancer therapy, but their genome sequence might contain information about their risk of developing Alzheimer's disease in old age. The questions are these: Should patients receive those "incidental findings" or not? And who decides?

The ACMG recommends that anyone undergoing genome sequencing for any reason should be tested for a list of clinically actionable conditions, including predispositions to various forms of cancer and to cardiomyopathy (but not to Alzheimer's disease). Furthermore, the recommendations are that physicians have a duty to then pass that information on to the patient, like it or not.

Not only would such an approach to medicine be a challenge for patient autonomy, but it would also be costly, the bioethicists say.

"It's not clear how those costs would be passed along, either to insurers or to patients themselves," Allyse said. "For the moment, from a patient perspective, the affected population is pretty small, because few people currently undergo whole-genome sequencing. But there are definitely signs that this practice is growing, especially in cancer diagnosis, and so we can envision that this issue of how to define and report incidental findings is likely to affect more and more people in the future. The issue of cost will of course affect any patient who has limited resources -- along with the hospitals, insurance companies, and government programs that pay for much of the care patients receive."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/ettsTf9Qb8w/130509123412.htm

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First Gravity Trailer: In Space, Silence Is Scarier Than Aliens

The thought of being ditched at sea isn't as terrible as being left behind in space. At least when you compare the trailers for Open Water and Alfonso Cuar?n's latest, Gravity. The synopsis for this space odyssey goes something like this:

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Oda68IDWQUY/the-trailer-for-gravity-is-breathtakingly-scary-499801470

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শুক্রবার, ১০ মে, ২০১৩

Myth killer: iPad magnet effect on defibrillators wasn't "discovered" by a 14-year-old

Those magnets in every iPad that allow the Smart Cover and Smart Case to attach securely have the ability to accidentally shut off implanted heart defibrillators if the iPad happens to be lying on the patient's chest. According to a Bloomberg news report yesterday, that discovery was made by Gianna Chien, a 14-year-old high school freshman who presented the results of her science fair project to doctors at a meeting of the Heart Rhythm Society in Denver yesterday.

Well, to be fair, Chien probably just read the iPad user guide, where the warning is plainly written:

iPad has magnets along the left edge of the device and on the right side of the front glass, which may interfere with pacemakers, defibrillators, or other medical devices. The iPad Smart Cover and iPad Smart Case also contain magnets. Maintain at least 6 inches (approximately 15 cm) of separation between your pacemaker or defibrillator and iPad, the iPad Smart Cover, or the iPad Smart Case.

Strong magnets (and not just those on an iPad) can affect defibrillators in several ways -- first, they can put the devices into a test mode that increases the heart rate depending on how much battery life is left in the defibrillator. Second, the defibrillators are designed to be shut off by magnets as a safety precaution. The iPad that Chien used was an iPad 2, which triggered the test mode in 30 percent of patients who put the tablet onto their chest.

While the Bloomberg article and headline provided some titillating reading, Chien didn't "discover" anything. Instead, the 14-year-old and her cardiac electrophysiologist father Walter just used 26 volunteers to test how commonplace the iPad magnet effect is. If Chien should be lauded for anything, it's waking the public up to actually reading those user guides and safety warnings that we all ignore on a regular basis.

In the meantime, if you have a defibrillator or pacemaker implant, don't put the iPad on your chest. Ever.


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Source: http://www.tuaw.com/2013/05/10/myth-killer-ipad-magnet-effect-on-defibrillators-wasnt-discov/

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Zachary Quinto picks his creepiest 'AHS' scene

TV

12 hours ago

Image: Zachary Quinto

Bravo

Zachary Quinto talks about what he thinks was the creepiest "AHS" scene he's had to do.

If Spock were capable of expressing emotion, he would be horrified by the characters Zachary Quinto has played in "American Horror Story."

Stopping by "Watch What Happens Live" as part of his promotional tour for the new "Star Trek Into Darkness" flick, in which the actor reprises his role as Spock, Quinto cheerfully fielded questions from fans.

When one caller asked him to name the creepiest scene he's filmed for "AHS," he recounted a particularly uncomfortable moment from season two.

In the "Asylum" scene, his sadistic psychiatrist Oliver Thredson ordered his lesbian patient Lana Winters to engage in an unusual method to "cure" her of her homosexuality.

"The weirdest scene I had to film was with my great friend Sarah Paulson. I was doing this aversion therapy ..." he said, laughing along with host Andy Cohen and fellow guest Alyson Hannigan. "It was really weird because we've been friends for a long time."

Fans of the creepy FX series likely know exactly which non-family-friendly scene the actor was describing.

"AHS" is full of eyebrow-raising moments, but Quinto spent half a year missing most of his bushy facial feature.

"For seven months I had to shave them," he grumbled good-naturedly about his "Star Trek" character's angled eyebrows. "It wasn't a good look for me. There was waxing, there was shaving. I (wore) a lot of glasses and hats."

Source: http://www.today.com/entertainment/zachary-quinto-picks-his-creepiest-american-horror-story-scene-1C9858217

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Video: Wednesday's Market Roadmap

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Source: http://www.nbcnews.com/video/cnbc/51816365/

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(AUDIO) Ronde Barber On Rome

(Photo by Kevin C. Cox/Getty Images)

(Photo by Kevin C. Cox/Getty Images)

Today on 98.7 The Fan, Jim Rome was joined by Ronde Barber to talk about his illustrious career. Ronde covered his time in Tampa, his place historically in the NFL, and what he will do with his life post football.? Barber says that a career in broadcasting could be in his future on a national level.

Tune in to The Jim Rome show every weekday from 12p-3p before Booger and Rich on Sports Radio 98.7 The Fan.

  • Ronde Barber w/Jim Rome 5/9/13
  • Jim Rome

Source: http://tampa.cbslocal.com/2013/05/09/audio-ronde-barber-on-rome/

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বৃহস্পতিবার, ৯ মে, ২০১৩

New insights into Ebola infection pave the way for much-needed therapies

Wednesday, May 8, 2013

The Ebola virus is among the deadliest viruses on the planet, killing up to 90% of those infected, and there are no approved vaccines or effective therapies. A study published by Cell Press on May 7th in the Biophysical Journal reveals how the most abundant protein making up the Ebola virus?viral protein 40 (VP40)?allows the virus to leave host cells and spread infection to other cells throughout the human body. The findings could lay the foundation for the development of new drugs and strategies for fighting Ebola infection.

"Little research is available on how the Ebola virus buds from the plasma membrane of human cells," says senior study author Robert Stahelin of Indiana University School of Medicine. "By shedding light on this process, our study will help us to identify potential drug candidates that could interfere with this step in the viral life cycle."

The Ebola virus is made up of seven proteins, including VP40, which plays a key role in enabling the virus to leave host cells and infect other cells in the human body. Past studies have shown that a part of VP40 called the C-terminal domain penetrates the plasma membrane surrounding host cells. But until now, it was not known exactly how VP40 binds to the plasma membrane to allow the virus to escape host cells.

To address this question, Stahelin and his team made vesicles designed to mimic the plasma membrane of host cells and exposed these vesicles to VP40. Observing their interactions under the microscope, they found that VP40's C-terminal domain penetrates more than halfway into one layer of the vesicles. VP40 also caused the vesicle membranes to bend into the shape of the Ebola virus, paving the way for its escape. When the researchers mutated the C-terminal domain of VP40, the protein was much less effective at binding to and bending membranes and forming virus-like particles that could escape from host cells.

Altogether, the findings reveal how VP40's C-terminal domain allows the Ebola virus to spread infection. "Currently, we are trying to find small molecules that can inhibit VP40 interactions with the plasma membrane," Stahelin says. "This effort could lead to the discovery of potential drug candidates that could form the basis of much-needed therapies for this deadly virus."

###

Biophysical Journal, Soni et al.: "The Ebola Virus Matrix Protein Deeply Penetrates the Plasma Membrane: An Important Step in Viral Egress."

Cell Press: http://www.cellpress.com

Thanks to Cell Press for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/128168/New_insights_into_Ebola_infection_pave_the_way_for_much_needed_therapies

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The Weirdest Thing on the Internet Tonight: Take Me to The Fog

No matter how advanced the invading alien culture, rest assured that humanity will find a way to fight back?be it the bacteria from War of the Worlds, Jeff Goldblum from Independence Day, or a pipe rip of the sticky icky from Stephen J Mitchell's awesome stop motion short, Take Me to the Fog.

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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/5-ou4HC9zz4/the-weirdest-thing-on-the-internet-tonight-take-me-to-496204939

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Oldest 'dome-headed' dinosaur discovered in Canada

A newly discovered dome-headed, dog-size dinosaur suggests that small dinos were more diverse than paleontologists have realized.

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The dinosaur, discovered in Alberta, Canada, is named Acrotholus audeti; Acrotholus means "high dome," as the new dinosaur was a pachycephalosaur, a group known for their thick, bony skulls. The new specimen is the oldest pachycephalosaur ever found in North America, and rivals the oldest specimen in the world, scientists report today (May 7) in the journal Nature Communications.

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"Acrotholus provides a wealth of new information on the evolution of bone-headed dinosaurs. Although it is one of the earliest known members of this group, its thickened skull dome is surprisingly well-developed for its geological age," study researcher David Evans, the curator of vertebrate paleontology at the Royal Ontario Museum, said in a statement. [Gallery: Gorgeous Dinosaur Fossils]

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The dinosaur roamed in what is now Alberta about 85 million years ago. That's 5 million years before the next known pachycephalosaur specimen found in North America. Another pachycephalosaur from Mongolia is approximately the same age as the new species.

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Paleontologists found fragments of the animal's skull ? more than 2 inches (10 centimeters) thick ? on the ranch of Roy Audet, whose surname gives the new species the second half of its scientific name.

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Given the diversity of small animals in modern times, researchers would expect to see that ancient ecosystems had a large share of tiny dinosaurs. But dinosaurs that weighed less than about 220 lbs. (100 kilograms) don't fossilize well. Any bones that weren't immediately scattered or weathered into dust were often washed away from the death site, leading to jumbled, confused fossil sites. Big beasts such as long-necked, bus-sized sauropods are easier to unearth.

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Most pachycephalosaurs weighed less than 88 lbs. (40 kg), or smaller than a well-fed Labrador retriever. But compared with other dinosaurs of that size, they are likely better represented in the fossil record, because their enormously thick skulls weather time and the elements better than the craniums of more delicate dinosaur species.

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Even so, Evans and his colleagues found that pachycephalosaur diversity has likely been underestimated by as much as a factor of five. That means the diversity of other small dinosaurs is even more unknown.

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"We can predict that many new small dinosaur species like Acrotholus are waiting to be discovered by researchers willing to sort through the many small bones that they pick up in the field," study researcher Michael Ryan, who curates vertebrate paleontology at the Cleveland Museum of Natural History, said in a statement.

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The Acrothoulus fossils are set to go on display at the Royal Ontario Museum this month.

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This story was originally written for LiveScience and was republished with permission here. Copyright 2013 LiveScience, a TechMediaNetwork company.

Source: http://www.mnn.com/earth-matters/animals/stories/oldest-dome-headed-dinosaur-discovered-in-canada

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